KIF3C Promotes the Malignant Progression of Lung Cancer Cells A549
نویسندگان
چکیده
Objective: To investigate the role of KIF3C gene in promoting malignant phenotype lung cancer cells and regulating PI3K/AKT signaling pathway. Methods: CCK-8 transwell assays were used to detect changes cell proliferation migration ability after being transfected with siKIF3C, as well protein expression levels PI3K, p-PI3K, AKT, p-AKT following downregulation by Western blot. Results: The assay showed that proliferation/viability A549 significantly reduced siKIF3C (P < 0.05); was p-PI3K proteins downregulated knockdown however, detection PI3K AKT not statistically significant. Conclusion: may promote through
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ژورنال
عنوان ژورنال: Proceedings of Anticancer Research
سال: 2022
ISSN: ['2208-3545', '2208-3553']
DOI: https://doi.org/10.26689/par.v6i6.4431